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Chimie moléculaire Paris Centre

Turning Capsule Catalysis Inside Out: Novel Approaches Utilizing Innately-Polarized Pd2L4 Scaffolds

Séminaire du Dr Paul Lusby (Edinburgh University)


Substrate pre-organization remains the paradigm for bio-inspired catalytic strategies using supramolecular capsule systems. The scarcity of capsule-catalyzed annulation reactions (A+B→C) highlights the limitation of this approach—while co-encapsulation can give significant acceleration, product inhibition frequently halts turnover.1,2 In this talk, two novel and distinct methods for realizing capsule-catalyzed annulation processes will be described, both involving the host-guest chemistry of simple Pd2L4 assemblies.3,4


1. J. Kang, J. Rebek, Nature, 1998, 385, 50; 2. M. Yoshizawa, M. Tamura, M. Fujita, Science, 2006, 312, 251; 3. D. P. August, G. S. Nichol, P. J. Lusby, Angew. Chem. Int. Ed. 2016, 55, 15022; 4. V. Marti-Centelles, A. L. Lawrence, P. J. Lusby, J. Am. Chem. Soc. 2018, DOI: 10.1021/jacs.7b12146.


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