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Chimie moléculaire Paris Centre
ÉCOLE DOCTORALE 406

Platforms for the generation and high-throughput screening of SICLOPPS cyclic peptide libraries.

Séminaire du Prof. Ali Tavassoli (University of Southampton)

Abstract

Cyclic peptide libraries have demonstrated significant potential when employed against challenging targets such as protein– protein interactions. SICLOPPS is a method for the intracellular generation of cyclic peptide libraries of over a hundred million members. We have interfaced SICLOPPS libraries with a variety of cell-based assays for the identification of inhibitors of a variety of targets.

The discovery and development of our cyclic peptide HIF-1 inhibitors will be discussed, along with details of a newly developed ultra-high throughput screening platform that allows the generation of SICLOPPS cyclic peptide libraries in femtolitre-sized microfluidic droplets.

21/03/18

Traductions :

    Contact

    Directrice 

    Anna Proust (anna.proust @ upmc.fr)

     

    Directeur adjoint

    cyril.ollivier @ upmc.fr

     

    Secrétariat

    Irène Rasoarinoro (irene.rasoarinoro @ upmc.fr)

    Tel. : 01 44 27 38 48

     

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