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Chimie moléculaire Paris Centre
ÉCOLE DOCTORALE 406

Platforms for the generation and high-throughput screening of SICLOPPS cyclic peptide libraries.

Séminaire du Prof Ali Tavassoli (University of Southampton)

Abstract :

Cyclic peptide libraries have demonstrated significant potential when employed against challenging targets such as protein– protein interactions. SICLOPPS is a method for the intracellular generation of cyclic peptide libraries of over a hundred million members. We have interfaced SICLOPPS libraries with a variety of cell-based assays for the identification of inhibitors of a variety of targets.

The discovery and development of our cyclic peptide HIF-1 inhibitors will be discussed, along with details of a newly developed ultra-high throughput screening platform that allows the generation of SICLOPPS cyclic peptide libraries in femtolitre-sized microfluidic droplets.

25/09/18

Traductions :

    Contact

    Directeur

    cyril.ollivier@sorbonne-universite.fr (cyril.ollivier @ upmc.fr)

     

    Directeur adjoint

     

     

    Secrétariat

    Irène Rasoarinoro (irene.rasoarinoro @ upmc.fr)

    Tel. : 01 44 27 38 48

     

    UPMC - ED 406

    Tour 32 - 42

    Bureau 114 (1er étage)

    BC 63 - 4 Place Jussieu 

    75252 Paris cedex 5