Aller au contenu Aller au menu Aller à la recherche

accès rapides, services personnalisés
Rechercher
Chimie moléculaire Paris Centre
ÉCOLE DOCTORALE 406

Multi kilogram-scale synthesis of an anticancer drug candidate: a journey towards development of some key reactions

Séminaire du Dr Christophe Hardouin (Oril Industrie)

Abstract :

. In order to evaluate a new drug in preclinical or clinical testing, the pharmaceutical industry needs bulk quantities of final product (from kg to hundreds of kg). Converting reactions from laboratory into industrial-scale manufacturing processes remains a challenge for process chemists while taking into account safety, legislation, environmental and cost of goods requirements.

As part of a drug discovery program at Servier Group, compound 1 was selected. To enable further clinical studies, we explored an efficient route to synthesize 1 implementing some key reactions.

Both strategy and scale up will be discussed.

15/11/18

Traductions :

    Contact

    Directeur

    cyril.ollivier@sorbonne-universite.fr (cyril.ollivier @ upmc.fr)

     

    Directeur adjoint

     

     

    Secrétariat

    Irène Rasoarinoro (irene.rasoarinoro @ upmc.fr)

    Tel. : 01 44 27 38 48

     

    UPMC - ED 406

    Tour 32 - 42

    Bureau 114 (1er étage)

    BC 63 - 4 Place Jussieu 

    75252 Paris cedex 5