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Chimie moléculaire Paris Centre
ÉCOLE DOCTORALE 406

Heterocycles from the sea, a light from the abyss

Séminaire du Dr Yves L. Janin (CNRS - Institut Pasteur)

Abstract :

A growing proportion of bioluminescent reporting systems are using imidazo[1,2-∝]pyrazine luciferins such as the natural product coelenterazine or the analog furimazine along with photoproteins or luciferases from sea creatures. Our contribution has led to an original (gram-scale) synthesis of this heterocyclic system, the preparation of close to 150 analogues and thus to extensive insights in the structure-bioluminescence relationship when using Nanoluc/nanoKaz as the luciferase.

12/09/18

Traductions :

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    cyril.ollivier@sorbonne-universite.fr (cyril.ollivier @ upmc.fr)

     

    Directeur adjoint

     

     

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    Irène Rasoarinoro (irene.rasoarinoro @ upmc.fr)

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