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Chimie moléculaire Paris Centre

Dienals as versatile substrates for the stereoselective synthesis of polycyclic architectures.

Séminaire du Dr Xavier Moreau (Université de Versailles Saint-Quentin-en-Yvelines)

Abstract :

Polycyclic architectures encompass a broad range of natural and biologically relevant products. The vast array of structural diversity and complexity reached by these molecules has fascinated synthetic organic chemists over the years. Within the context of total synthesis or synthetic chemistry methodology, considerable endeavors have been devoted to the design of efficient domino transformations that generate elaborated polycyclic tridimentional scaffolds bearing multiple stereogenic centers. Beyond that, diversity-oriented synthesis (DOS) based around readily available and versatile starting materials is one of the most attractive strategy to achieve skeletal diversity. Thus, merging domino polycyclizations with DOS approach could lead to intricate small-molecule libraries. In this context, our current interest in designing new methodologies to afford functionalized polycyclic scaffolds from simple unsatured aldehydes will be presented.


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