Copper(I/II) complexes with the peptide amyloïd-ß: structure, reactivity and biological relevance
Séminaire du Pr Peter Faller (Institut de chimie de Strasbourg, Université de Strasbourg)
Copper is an essential element and is needed for several essential purposes such as energy production. Copper ions are generally tightly bound at specific sites to proteins. Copper inappropriately bound, often called labile or loosely bound copper, can be a very good catalyst for the production of reactive oxygen species (ROS). Thus copper metabolism has to be tightly controlled. There is a mutlitude of studies reporting a connection between Alzheimer disease (AD) and copper metabolism. In AD, the peptide amyloïd-ß (Aß) forms plaques, which contain a high amount of Cu ions. This Cu bound Aß is thougnt to contribute to the production of ROS observed in AD. We are interested in the in vitro reactivity of ROS production by of Cu-Aß and other biological relevant peptides. The seminar reports on the recent advancements in this field.