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Chimie moléculaire Paris Centre
ÉCOLE DOCTORALE 406

Chemical Biology Tools to Perceive and Perturb Carbohydrates and Carbohydrate Processing Enzymes in Living Systems

Séminaire du Pr David Vocadlo (Simon Fraser University) - Amphi 45B

Abstract

The carbohydrate structures found in every kingdom of life are emerging as a frontier area of chemical biology. I discuss our efforts to create new chemical biology tools for studying these structures and the enzymes that process them within cells and in animal models. Topics will be selected from the synthesis and deployment of ; (i) a new family of fluorescence-quenched substrates that permit quantitative imaging of glycoside hydrolase activities in live cells by high content imaging, (ii) the design, synthesis and creation of potent and selective inhibitors of carbohydrate processing enzymes active in cells and in vivo and (iii) new chemical genetic methods to map glycosylation to the genome.

25/10/17

Traductions :

    Contact

    Directrice 

    Anna Proust (anna.proust @ upmc.fr)

     

    Directeur adjoint

    Matthieu Sollogoub (matthieu.sollogoub @ upmc.fr)

     

    Secrétariat

    Irène Rasoarinoro (irene.rasoarinoro @ upmc.fr)

    Tel. : 01 44 27 38 48

     

    UPMC - ED 406

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