Aller au contenu Aller au menu Aller à la recherche

accès rapides, services personnalisés
Chimie moléculaire Paris Centre

Chemical Biology Tools to Perceive and Perturb Carbohydrates and Carbohydrate Processing Enzymes in Living Systems

Séminaire du Pr David Vocadlo (Simon Fraser University) - Amphi 45B


The carbohydrate structures found in every kingdom of life are emerging as a frontier area of chemical biology. I discuss our efforts to create new chemical biology tools for studying these structures and the enzymes that process them within cells and in animal models. Topics will be selected from the synthesis and deployment of ; (i) a new family of fluorescence-quenched substrates that permit quantitative imaging of glycoside hydrolase activities in live cells by high content imaging, (ii) the design, synthesis and creation of potent and selective inhibitors of carbohydrate processing enzymes active in cells and in vivo and (iii) new chemical genetic methods to map glycosylation to the genome.


Traductions :



    Anna Proust (anna.proust @


    Directeur adjoint

    cyril.ollivier @



    Irène Rasoarinoro (irene.rasoarinoro @

    Tel. : 01 44 27 38 48


    UPMC - ED 406

    Tour 32 - 42

    Bureau 114 (1er étage)

    BC 63 - 4 Place Jussieu 

    75252 Paris cedex 5