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Chimie moléculaire Paris Centre
ÉCOLE DOCTORALE 406

Advancing synthetic chemistry in biological media

Séminaire du Pr Alain Wagner (Chimie BioFonctionnelle UMR 7199 Illkirch France)

Abstract

Our research focuses on the development of chemical reactions that are compatible with complex biological media. They are qualified as bioorthogonal when they can take place in a complex biological medium without distorting it, or as bio-specific when they touch only a precise part of it.

Taking advantage of imaging and bioanalytical methods, we have developed original chemometric methodologies to figure the bio-reactivity profile of bond-forming and bond-breaking chemical reactions. By applying this methodology, we were able to characterize novel functional groups and reagents that exhibit a precise activation profile and to uncover unexpected biospecificity. Applications to bioconjugation, in vivo drug neutralization and chemoselective metabolomic approaches will be described.

14/09/17

Traductions :

    Contact

    Directrice 

    Anna Proust (anna.proust @ upmc.fr)

     

    Directeur adjoint

    Matthieu Sollogoub (matthieu.sollogoub @ upmc.fr)

     

    Secrétariat

    Irène Rasoarinoro (irene.rasoarinoro @ upmc.fr)

    Tel. : 01 44 27 38 48

     

    UPMC - ED 406

    Tour 32 - 42

    Bureau 114 (1er étage)

    BC 63 - 4 Place Jussieu 

    75252 Paris cedex 5