Aller au contenu Aller au menu Aller à la recherche

accès rapides, services personnalisés
Chimie moléculaire Paris Centre

Activatable Lanthanide complexes: Probes for multimodal imaging of an enzyme activity

Séminaire du Dr Philippe Durand (Institut de Chimie des Substances Naturelles (ICSN), Gif-sur-Yvette (UPR 2301)

Abstract :

While enzyme activity is routinely determined using in vitro assays, its in vivo visualization remains a challenge. This is a subject of increasing interest in molecular imaging since dysregulation of these biological catalysts is associated with many diseases. In this context, we designed lanthanide-based probes that are responsive to a specific enzyme activity (-galactosidase for instance). These probes can be monitored by one to three different modalities depending on the lanthanide used: T1-MRI, paraCEST-MRI and optical imaging. The design, synthesis and magnetic/optical properties of prototypes will be presented.


Traductions :



    Dr Cyril OLLIVIER (cyril.ollivier @


    Directeur adjoint PSL

    Dr Fethi BEDIOUI (fethi.bedioui @



    Emmanuelle BLIN (emmanuelle.blin.1 @ (ED406-secretariat @

    Tel. : 01 44 27 38 48

    SU - ED 406

    Tour 32 - 42

    Bureau 114 (1er étage)

    BC 63 - 4 Place Jussieu 

    75252 Paris cedex 5


    Annuaire doctorants