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Chimie moléculaire Paris Centre
ÉCOLE DOCTORALE 406

Activatable Lanthanide complexes: Probes for multimodal imaging of an enzyme activity

Séminaire du Dr Philippe Durand (Institut de Chimie des Substances Naturelles (ICSN), Gif-sur-Yvette (UPR 2301)

Abstract :

While enzyme activity is routinely determined using in vitro assays, its in vivo visualization remains a challenge. This is a subject of increasing interest in molecular imaging since dysregulation of these biological catalysts is associated with many diseases. In this context, we designed lanthanide-based probes that are responsive to a specific enzyme activity (-galactosidase for instance). These probes can be monitored by one to three different modalities depending on the lanthanide used: T1-MRI, paraCEST-MRI and optical imaging. The design, synthesis and magnetic/optical properties of prototypes will be presented.

31/01/20

Traductions :

    Contact

    Directeur

    cyril.ollivier@sorbonne-universite.fr (cyril.ollivier @ upmc.fr)

     

    Directeur adjoint

     

     

    Secrétariat

    Irène Rasoarinoro (irene.rasoarinoro @ upmc.fr)

    Tel. : 01 44 27 38 48

     

    SU - ED 406

    Tour 32 - 42

    Bureau 114 (1er étage)

    BC 63 - 4 Place Jussieu 

    75252 Paris cedex 5