Les séminaires CulturChem

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    25.06.2018 - 25.06.2018

    Bio-inspired peptide-like ligands to help understanding metal toxicity, regulation and detoxification

    Séminaire du Dr Pascale Delangle (CEA Grenoble, France)
    Abstract :
    Peptides are promising metal-chelating agents, which offer many advantages over synthetic chemical compounds for biological and medical applications. They are made of the same building blocks as proteins and are therefore excellent mimics of biological sites that help predicting high affinity metal binding environments in vivo. They...
    

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    18.06.2018 - 18.06.2018

    Dearomatizations of Nitroarenes by additions and cycloadditions

    Séminaire du Dr Isabelle Chataigner (Université de Rouen Normandie)
    Abstract :
    . Involving arenes in dearomatizing addition and/or cycloaddition reactions is an attractive and convergent approach to construct complex polycycles from easily accessible substrates, however, challenging because of their intrinsic stability.
    Nitroarenes are interesting substrates in this context, allowing to carry out various...
    

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    11.06.2018 - 11.06.2018

    Developing hybrid architectures embedding Single Molecule Magnets for spintronics

    Séminaire du Dr Matteo Mannini
    Abstract :
    The use of magnetic molecule discloses new exciting possibilities for spintronics and quantum computing linked to the individual properties of these molecular units as well as to their interaction with specific surfaces. However, the coupling of molecules with the spin-transport processes is far from trivial. First, the stability of molecules in the device environment...
    

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    14.05.2018 - 14.05.2018

    Platforms for the generation and high-throughput screening of SICLOPPS cyclic peptide libraries.

    Séminaire du Prof. Ali Tavassoli (University of Southampton)
    Abstract
    Cyclic peptide libraries have demonstrated significant potential when employed against challenging targets such as protein– protein interactions. SICLOPPS is a method for the intracellular generation of cyclic peptide libraries of over a hundred million members. We have interfaced SICLOPPS libraries with a variety of cell-based assays...
    

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    19.03.2018 - 19.03.2018

    Stimuli responsive polymeric materials via host-guest interactions

    Séminaire du Dr Yoshinori Takashima (Osaka University)
    Abstract
    Molecular recognition chemistry and supramolecular chemistry have received much attention, owing to their effects on catalytic activity, molecular switches, and materials.  Stimuli-responsive supramolecular polymers is relevant not only for biological functions but also for a range of other applications.  Our research group has employed...
    
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    05.03.2018 - 05.03.2018

    Chimie et biophotonique : de la chimie moléculaire à l’imagerie subcellulaire

    Séminaire du Dr Claude-Marie Bachelet (Inserm)
    Abstract
    Nous ferons un tour d’horizon des techniques développées en microscopie en lien avec les marqueurs chimiques associés, dans les études du vivant en temps réel, comme approche technologique interdisciplinaire pour l’analyse des mécanismes biologiques.
    

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    26.02.2018 - 26.02.2018

    Combining N-heterocyclic carbenes (NHCs) with oxophilic and earth-abundant metal centers: fundamental reactivity and use in homogeneous catalysis

    Séminaire du Dr Samuel Dagorne (Institut de Chimie, CNRS - Université de Strasbourg)
    Abstract
    The development of earth-abundant, affordable and low toxic metal-based catalysts is of current strategic importance for sustainable catalytic processes. In this context, the organometallics of oxophilic and high-oxidation state metal centers, such as Zn(II) and Al(III), holds a particular interest in catalysis...
    

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    19.02.2018 - 19.02.2018

    Chimie coordination des lanthanides : des molécules-aimants au marqueurs luminescents anti-contrefaçon

    Séminaire du Dr Kevin Bernot (INSA-Rennes, ISCR, Université de Rennes 1
    Abstract
    La chimie de coordination des ions lanthanides permet de synthétiser une incroyable variété de matériaux moléculaires, du plus simple (molécule isolée) au plus élaboré (réseau tridimensionnel de molécules fonctionnelles).
    Ces concepts seront illustrés par des exemples récents de l’activité de notre équipe dans le domaine...
    

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    12.02.2018 - 12.02.2018

    Détecter les pathogènes en leurrant leur métabolisme

    Séminaire du Dr Boris Vauzeilles (Institut de Chimie Moléculaire et des Matériaux d'Orsay et ICSN, Paris-Saclay)
    Abstract
    La détection et l’identification rapides de bactéries est un défi majeur de santé publique. L’approche que nous développons repose sur le marquage métabolique de la surface cellulaire. A titre d’exemple, la paroi externe des bactéries dites à Gram négatif est recouverte par une...
    

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    05.02.2018 - 05.02.2018

    Reverse Engineering in Metal-Catalyzed Processes

    Séminaire du Dr Laurence Grimaud (Laboratoire Pasteur, ENS, Paris)
    Abstract
    Mechanistic studies are of utmost importance for the rationale development of new reactions. Indeed, a better understanding of the molecular process is still required especially for transition metal-catalyzed reactions, for which the development of new methodologies continues at a fast pace and still takes place by trial and...
    
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    29.01.2018 - 29.01.2018

    Metal-mediated Quadruplex Assemblies with and without DNA

    Séminaire du Pr Guido Clever (TU Dortmund)
    Abstract :
     We employ the square-planar metal(pyridine)4-motif in the self-assembly of quadruply stranded supramolecular architectures based on various organic and DNA-derived ligands. The talk will highlight functional assemblies including reversibly stabilized DNA-quadruplexes and guest-binding coordination cages. A focus will be laid on stimuli-responsive...
    

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    22.01.2018 - 22.01.2018

    Functionnalization of layered hydroxides and oxide materials: insertion, grafting, in situ reactions…and microwaves

    Séminaire du Dr Guillaume Rogez (IPCMS, Université de Strasbourg)
    Abstract
    Since the discovery of the outstanding properties of graphene or metal dichalcogenides single layers,[research in the domain of functional nanomaterials based on nanosheets and 2D materials has received ever growing attention. In this respect, the organic-inorganic hybrid material approach seems particularly promising to promote...
    

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    15.01.2018 - 15.01.2018

    Mechanistic studies of the enzymes that make dihydrogen

    Séminaire du Dr Christophe Léger (BIP, Université d'Aix Marseille)
    Abstract
    The enzymes that consume or produce « solar fuels » are large protein complexes that embed inorganic cofactors. Understanding their mechanisms requires a combination of biochemistry, molecular biology, spectroscopy, crystallography, theoretical chemistry and kinetics. As part of kinetics, electrochemistry has become very important...
    

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    18.12.2017 - 18.12.2017

    Molecular Behavior in a Small Space

    Séminaire du Pr Julius Rebek, Jr (The Scripps Research Institute and Shanghai University)
    Abstract
    This lecture describes molecular behavior in synthetic receptors that completely surround their targets: encapsulation complexes. Topics include the new forms of stereochemistry, amplified interactions, chiral spaces and reactivity of molecules confined to a small space. The composition of the capsule...
    

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    11.12.2017 - 11.12.2017

    Breaking the limits in investigating Glycan-Protein Interactions by using NMR

    Séminaire du Dr Jésus Jimenez Barbero (CIC bioGUNE, Spain)
    Abstract
    Molecular recognition by specific targets is at the heart of the life processes. In recent years, it has been shown that the interactions between proteins (lectins, enzymes, antibodies) and carbohydrates mediate a broad range of biological activities, from fertilization, embryogenesis, and tissue maturation, to pathological processes...
    
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    04.12.2017 - 04.12.2017

    Redox-active self-assembled cages

    Séminaire du Pr Marc Sallé (MOLTECH-Anjou, UMR CNRS 6200, Univ. Angers)
    Abstract
    While molecular cages are often challenging to prepare through covalent chemistry procedures, the metal-driven self-assembly methodology allows a straightforward access to a wide variety of discrete architectures. The resulting cavities offer promising opportunities for applications in host-guest chemistry. In this context...
    

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    13.11.2017 - 13.11.2017

    New Phospha-helicenes: Synthesis and Applications in Asymmetric Catalysis

    Séminaire du Dr Arnaud Voiturier (CNRS-ICSN, Gif-sur-Yvette)
    Abstract
    Over the past few years, helicenes have attracted considerable attention due to their wide potential, notably in materials science. However, molecular scaffolds with helical chirality have been rarely used for building phosphorus ligands and catalysts. In this context, our goal was to access unprecedented chiral auxiliaries for organo-...
    

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    16.10.2017 - 16.10.2017

    Studies of Lanthanoid Single-Molecule Magnets

    Séminaire du Pr Colette Boskovic (The University of Melbourne)
    Abstract
    The slow magnetisation relaxation and quantum tunnelling exhibited by single-molecule magnets (SMMs) may see them as the basis of future molecular spintronics devices or quantum computers.  We are presently exploring the development of new lanthanoid-based SMMs that incorporate redox-active ligands.  Another focus is elucidation...
    

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    02.10.2017 - 02.10.2017

    Advancing synthetic chemistry in biological media

    Séminaire du Pr Alain Wagner (Chimie BioFonctionnelle UMR 7199 Illkirch France)
    Abstract
    Our research focuses on the development of chemical reactions that are compatible with complex biological media. They are qualified as bioorthogonal when they can take place in a complex biological medium without distorting it, or as bio-specific when they touch only a precise part of it.
    Taking advantage of imaging...
    

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    18.09.2017 - 18.09.2017

    Transition de spin photo-induite : développements récents

    Séminaire du Prof Guillaume Chastanet (ICMCB, Université de Bordeaux)
    Abstract
    Depuis le début des années 80, la commutation optique de complexes de Fe(II) à conversion de spin a suscité un engouement notable puisqu’elle laissait envisager des processus ultrarapides, à l’échelle de la molécule. Nous verrons que la photocommutation ne se restreint plus aux composés à conversion de spin et que la conception...
    
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    11.09.2017 - 11.09.2017

    Functional PolyAromatics: a little flexibility in Molecular Recognition and Gold Complexes

    Séminaire du Prof Brigitte Bibal (ISM - UMR 5255, Université de Bordeaux)
    Abstract
    Our research aims to design modular polyaromatic compounds devoted to catalysis and molecular recognition. In this seminar, we will focuss on 9,10-diphenylanthracene and its unique photochemical and photophysical properties. Its switchable function was highlighted within a molecular cage that binds cations in an adjustable...