Les séminaires CulturChem

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    27.09.2021 - 27.09.2021

    (Multi)-catalytic strategies, synthetic economies... and some supramolecular applications

    Séminaire du Dr Adrien Quintard (Aix-Marseille University - CNRS)
    Abstract :
    The presentation will highlight our recent success in the development of multi-catalytic transformations. Based on the combinations between inexpensive iron or copper complexes with organocatalysts, they enable the rapid preparation of a broad range of molecules of interest. This was demonstrated in the context of natural products...
    

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    06.04.2020 - 06.04.2020

    Non-Precious Metal-Catalyzed Oxidant Free (De)-hydrogenation of Alcohols for Organic Transformations

    Séminaire du Dr Debasis Banerjee (Indian Institute of Technology Roorkee, India)
    Abstract :
    Recently, there is a potential drive to replace the precious noble-metal catalysts using earth abundant and inexpensive non-noble metals for sustainable organic transformations. We have studied the applications of Ni-, Fe- and Mn-based catalysts for selective construction of amines, amides, five or six-membered...
    

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    23.03.2020 - 23.03.2020

    L’analyse des données en métabolomique : un passage obligé

    Séminaire du Pr Alain Paris (Muséum national d’Histoire naturelle, UMR 7245 – MCAM)
    Abstract :
    Dans le champ de la chimie analytique, l’amélioration continue réalisée sur les deux dernières décennies des performances intrinsèques de détection des molécules, que ce soit par spectrométrie de masse ou par résonance magnétique nucléaire (RMN), a renouvelé la manière de caractériser le fonctionnement métabolique...
    

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    16.03.2020 - 16.03.2020

    Organometallic chemistry of low-valent lanthanides: unusual oxidation states and magnetic sandwiches

    Séminaire du Dr Grégory Nocton (Ecole Polytechnique)
    Abstract :
    Organolanthanide complexes are an interesting class of organometallic compounds that have been developed in the 1950’s and that now concern most of the rare earths in their trivalent and divalent states. The applications for such compounds are numerous for single electron transfer reactivity and also because of their optical and magnetic...
    

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    09.03.2020 - 09.03.2020

    From classic BODIPY to multifunctional Wazaby platform

    Séminaire du Prof. Ewen Bodio (ICMUB – Université Bourgogne-Franche-Comté)
    Abstract :
    BODIPY is one of the most versatile fluorophore (high quantum yield, high brightness, stable, synthesizable at gram-scale…), but its emission in the visible region of light spectrum and its poor water-solubility hamper its use for in vivo applications. This lecture will describe how the optimization a BODIPY-based...
    
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    02.03.2020 - 02.03.2020

    The power of chemoselectivity: functional protein-conjugates for intra- and extracellular targeting

    Séminaire du Dr Christian P. R. Hackenberger (Humboldt University of Berlin)
    Abstract :
    Our lab aims to identify new bioorthogonal reactions for the synthesis and modification of functional peptides and proteins. We apply these highly selective organic reactions1 to study functional consequences of naturally occurring posttranslational protein modifications (PTMs), in particular phosphorylated Lys-...
    

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    24.02.2020 - 24.02.2020

    Anion detection through control and activation of halogen bonding triggering by electrochemistry

    Séminaire du Dr Claire Fave (LEM UR 7591, Université de Paris)
    Abstract :
    Non-covalent interactions are crucial and of increasing interest in “supramolecular electrochemistry” concerning redox properties of supramolecular assemblies in solution. The importance of halogen bonding, an only recently described non-covalent interaction, is nowadays fully recognized. In this context we have shown the electrochemically...
    

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    17.02.2020 - 17.02.2020

    Activatable Lanthanide complexes: Probes for multimodal imaging of an enzyme activity

    Séminaire du Dr Philippe Durand (Institut de Chimie des Substances Naturelles (ICSN), Gif-sur-Yvette (UPR 2301)
    Abstract :
    While enzyme activity is routinely determined using in vitro assays, its in vivo visualization remains a challenge. This is a subject of increasing interest in molecular imaging since dysregulation of these biological catalysts is associated with many diseases. In this context,...
    

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    10.02.2020 - 10.02.2020

    Disclosing reactions mechanisms: what can we learn from theoretical approaches?

    Séminaire du Dr Ilaria Ciofini (CNRS/Chimie ParisTech)
    Abstract :
    The development of computationally affordable yet accurate methods for the description of ground and excited state reactivity of molecular species in solution and more complex environments, made in-silico modelling a powerful, and complementary approach to experimental studies, to disclose reactions mechanisms. In this lecture, through...
    

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    03.02.2020 - 03.02.2020

    From a screening of the Curie-CNRS Chemical Library to a drug in clinical phase for ulcerative colitis & From DNA fluorescent probes to fluorescent biosensor for protein-protein interaction

    Séminaire du Dr Mahuteau-Betzer (Institut Curie)
    Abstract :
    . In the first part, a success story of the screening of the Curie-CNRS chemical library will be described. This led to the discovery of alternative splicing inhibitors, one of them is currently in phase 2b for ulcerative colitis.
    In the second part, we will focus on the development of fluorescent biosensors for the detection of protein-protein...
    
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    27.01.2020 - 27.01.2020

    Dipyrrin-based self-assembled architectures

    Séminaire du Dr Stéphane Baudron (CNRS-Université de Strasbourg UMR 7140)
    Abstract :
    Dipyrrins are bis-pyrrolic derivatives that can be rather easily synthesized and functionalized, forming monoanionic chelates under mild basic conditions. These features make them interesting ligands for the elaboration of discrete and infinite metal-organic architectures. In particular, our efforts have centered on...
    

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    13.01.2020 - 13.01.2020

    From antibodies to MOFs: a full set of envelopes for metal cofactors in order to build up new artificial metalloenzymes

    Séminaire du Pr Jean-Pierre Mahy (Paris-Saclay University)
    Abstract :
    . Our group has long been involved in the production of artificial Metalloenzymes that have been found able to catalyze stereo-selective oxidation of chemicals by H2O2, RNAse like hydrolysis of oligonucleotides and stereoselective Diels-Alder reactions. The most recent developments of our research will be presented here:
    - The design...
    

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    06.01.2020 - 06.01.2020

    Reaxys, a searching database that helps you daily in your research and lab work !

    Séminaire des Drs Nadège Krebs et Juan Pablo Aita Vassallo (Reaxyx, Elsevier Lifesciences)
    Abstract :
    Every scientist needs to optimize his/her time. Finding relevant references in the literature, sorting out the results, getting answers to precise questionsin an ergonomic way, while being complete and exhaustive, is an everyday-challenge. Reaxys is a search and excerption database in chemistry (organic...