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Chimie moléculaire Paris Centre

Notre École Doctorale a pour but de préparer au plus haut niveau des étudiants à une activité professionnelle dans le domaine de la chimie moléculaire en utilisant les formidables atouts dont bénéficie Paris Centre

L’ED 406 rassemble des laboratoires et des équipes répartis sur plusieurs sites et établissements d’enseignement supérieur : Université Pierre et Marie Curie, Ecoles d’Ingénieurs ESPCI et Chimie Paris Tech, Muséum National d'Histoire Naturelle, CNAM, Collège de France, ENS.



    • Post-Synthetic Methods on MOFs : Chemical Reactors for Advanced Materials

      Séminaire du Dr Jésus Ferrando-Soria (ICMol, University of Valencia)
      My present work aims at making a breakthrough step-change on the use of metal-organic frameworks (MOFs) as nano-reactors. Our synthetic strategy is based on the design of MOFs with tailor-lade functional channels used as chemical reactors and solid-state post-synthetic methods. Using this approach, we show that novel species...

    • Efficient ligand platforms from our group for enantioselective catalysis

      Séminaire du Pr Anton Vidal (Institute of Chemical Research of Catalonia, Tarragona)
      Our research interests encompass the design of efficient enantioselective catalysts for transformations of interest, and the study of their use to prepare enantiomerically enriched products of biological, or pharmaceutical relevance. Crucial aspects of this work include modular design of the catalysts ; use...

    • Présences CulturChem 2016-2017

      Présences CulturChem 2016-2017

    • Can we make life in the lab ? Emergence and evolution of self-replicating molecules from dynamic molecular networks

      Séminaire du Pr Sijbren Otto (University of Groningen, the Netherlands)
      How the immense complexity of living organisms has arisen is one of the most intriguing questions in contemporary science. We have started to explore experimentally how organization and function can emerge from complex molecular networks in aqueous solution. We focus on networks of molecules that can interconvert, to give...

    • Asymmetric catalysis using ferrocene catalysts and organocatalysts

      Séminaire du Pr Radovan Sebesta (Comenius University in Bratislava, Slovakia)
      The lecture will focus on stereoselective domino reactions with organometallics, organocatalytic synthesis of pharmaceutical compounds, and synthesis of chiral ferrocenes. Stereoselective domino reactions using activated alkenes and naked carbenium ions in the Cu-catalyzed 1,4-additions of organometallic reagents...

    • A fully synthetic carbohydrate-based vaccine for cancer

      Séminaire du Pr Geert-Jan Boons (Utrecht University, The Netherlands)
      A common feature of oncogenic transformed cells is the over-expression of unusual oligosaccharides such as Globo-H, LewisY, Muc-1 and Tn. Numerous studies have shown that this abnormal glycosylation can promote metastasis and hence its expression is strongly correlated with poor survival rates of cancer patients. Several...

    • Water Oxidation Catalysts for Artificial Photosynthesis : Bio-inspired vs. Solid State Design Pathways

      Séminaire du Pr Greta R. Patzke (University of Zurich, Switzerland)
      The development of efficient water oxidation catalysts (WOCs) is a crucial bottleneck on the way to the implementation of artificial photosynthesis as an elegant pathway to directly convert inexhaustible solar resources into chemical fuels. The worldwide quest for WOCs is both inspired by bio-inspired concepts and robust solid...

    • Catalyse organométallique bio-orthogonale en système biologique

      Séminaire du Pr Olivier Riant (Université catholique de Louvain, Belgique)
      Le développement de réactions de catalyse par les métaux de transition dans les systèmes biologiques est un domaine émergeant et encore peu exploré, et qui offre un terrain de jeux fascinant aux interfaces de la chimie et de la biologie. Notre groupe s’est récemment intéressé à cette problématique et les premiers résultats...

    • Merging carbohydrate and superacid chemistries to explore glycosyl transfer

      Séminaire du Pr Yves Blériot (Université de Poitiers)
      The central reaction in glycosciences is arguably glycosylation, the formation of the glycosidic bond that connects a sugar motif to another molecule. It can be performed enzymatically through the use of glycosyl transferases or chemically using glycosyl donors and acceptors. Surprisingly, while the enzymatic mechanism has gained a high...

    • Synthesis of metal nanoparticles inspired by molecular chemistry concepts and their application in catalysis

      Séminaire du Dr Karine Philippot (LCC-CNRS, Toulouse)
      Concepts from molecular chemistry are useful to develop efficient synthetic tools in nanochemistry to achieve very small and well-defined metal nanoparticles.1 A careful choice of the metal-organic complex and stabilizing agent used as precursors allows tuning the characteristics and surface properties of the particles that are among main...

    • Advances in Phosphorus based Molecular Materials

      Séminaire du Pr Muriel Hissler (ISCR, Université de Rennes1, France)
      π-Conjugated oligomers and polymers based on heterocyclopentadienes have attracted strong interest in recent years owing to their potential applications for electronic devices. Their properties depend on the energy gap (Eg) which is affected by different factors involving planarity, aromaticity and electronic nature of the...

    • Annonce de post-doc Hebrew University, Jérusalem, Israël

      post-doc position

    • On the Medicinal Chemistry of N-Heterocyclic Carbene Metal Complexes

      Séminaire du Pr Ingo OTT (Technische Universität Braunschweig, Germany)
      Organometallics with N-heterocyclic carbene (NHC) ligands are widely used in chemistry because of their catalytic properties. The increasing application of this type of organometallics has also triggered a steadily rising number of studies in the field of medicinal chemistry. In fact it has been demonstrated that metal...

    • What do we really know about the mechanism of action of platinum anticancer agents ?

      Séminaire du Pr Dan Gibson (Hebrew University, Jerusalem, Israel)
      Cisplatin is one of the most successful and widely used anticancer agents. The accidental discovery of the anticancer activity of the metal complexes, followed by its approval by the FDA, triggered a new field of research – metal complexes as anticancer agents.  Decades of intensive research yielded two more platinum complexes...

    • Combining Software Development, advanced organic synyhesis and biophysical methods for efficient drug discovery

      Séminaire du Pr Nicolas Moitessier
      Abstract :
      Molecular discovery is often a long, iterative, cost-inefficient and environmentally infriendly process. More specifically, discovering asymmetric catalysts for chiral drug synthesis or novel therapeutics takes years and efforts to improve this process must be made. Our approach combines software development (ie, covalent drug docking), computational chemistry...

    • Hydrazones as Key Reagents and Ligands for Novel Applications in Asymmetric Catalysis

      Séminaire du Dr Rosario Fernandez (University of Seville, Spain)
      Abstract :
      The asymmetric 1,2 addition of formyl anion equivalents to carbonyl compounds is a powerful synthetic tool that provides a direct access to functionalized carbinols. In this context, we have exploited the aza-enamine character of formaldehyde N,N-dialkyl-hydrazones, but the development of a catalytic enantioselective version...

    • Liste des allocataires 2016

      Liste principale des candidats financés par l'ED 406
      Liste des allocataires 2016

    • Role of Molecular Modelling in the Design of Novel Magnetic Materials

      Séminaire du Dr Gopalan Rajaraman (IIT Bombay, Mumbai, India)
      Abstract :
      Molecular Magnets have wide spread potential applications ranging from magnetic storage devices, spintronics, Q-bits in quantum computing to magnetic coolants. Single-molecule magnets (SMMs) are the molecules which show slow relaxation of magnetization below the critical temperature and exhibit hysteresis loop similar to classical...

Mots clés

Synthèse organique, catalyse organométallique, chimie des substances naturelles ; réactions de couplage, radicalaires, domino ; catalyse asymétrique ; processus éco-compatibles. 

Synthèse et manipulation de biomolécules ; protéomique et spectrométrie de masse. 

Etude structure et réactivité d’enzymes ; chimie bio-organométallique. Synthèse inorganique, espèces polymétalliques ; complexes bio-inspirés ; catalyse de polymérisation biosourcée. 

Matériaux moléculaires pour l’ (opto)-électronique et le magnétisme, photovoltaïsme. 

Chimie supramoléculaire, cyclodextrines. Analyse et catalyse électrochimiques, biocapteurs electroanalytiques, sondes multimodales pour l’imagerie.




Anna Proust (anna.proust @


Directeur adjoint

Matthieu Sollogoub (matthieu.sollogoub @



Irène Rasoarinoro (irene.rasoarinoro @

Tel. : 01 44 27 38 48


UPMC - ED 406

Tour 32 - 42

Bureau 114 (1er étage)

BC 63 - 4 Place Jussieu 

75252 Paris cedex 5